Email. AY Hung, M Sheng. Find us on Twitter. msheng@mit.edu. This position in the Stanley Center for Psychiatric Research involves bioinformatics analysis in areas such as transcriptomics, neurophysiology, and behavior. Currently, the Sheng lab focuses on three areas of research: Immune response to infection and vaccination: We develop computational methods to study immune responses of humans and animal models. (+1) 617-324-0305 Postdoctoral fellows are expected to develop a research program that will provide the foundation for a future independent research career. Gong Lab. Phone. An official website of the United States government, Assistant Clinical Investigators (ACI) and Independent Research Scholar (IRS), NINDS BEACON Program - Building Engagement and Community for Nurses, Office of Research Training & Career Development, Lab Research Highlighted in NIH Press and Journals. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. He joined NINDS as an investigator in 1997 and is now a tenured senior investigator and Chief of Synaptic Functions Section at National Institute of Neurological Disorders and Stroke (NINDS), NIH. US 5849868 A Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue, From: https://picower.mit.edu/morgan-sheng, A physician and a scientist, Morgan Sheng. LinkedIn profile The labhas used a broad range of approaches to tackle these problems, notably the development of neuronal cultures from adult disease mouse models and live imaging of various organelle transport. Background and aimsAs a result of increasing numbers of studies most recently, mitophagy plays a vital function in the genesis of cancer. Job Description The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The mission of the Stanley Center is to improve the lives of patients suffering from serious mental illnesses, through groundbreaking basic and translational research. Sheng is a fellow of the Royal Society (UK), a fellow of the Academy of Medical Sciences (UK), a fellow of the American Association for the Advancement of Science, and honorary fellow of Corpus Christi College, Oxford. Dr. Sheng Ding is currently William K. Bowes, Jr. His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu). Our group aims to redesign existing proteins and engineer new proteins that overcome these limitations. The successful candidate will join a multidisciplinary group and perform cutting-edge basic and/or translational research on the molecular, cellular and neurobiological mechanisms of psychiatric disorders, especially in relation to risk genes for schizophrenia and bipolar disorder, synapse development/elimination, synaptic function/plasticity, neuron-glia interactions, and neural circuitry/interneurons. Current Youth Development Coordinator at David Scott School - Brotherhood of St Laurence, responsible for developing and creating industry immersion events with the desire of expanding students' future horizons by facilitating career development programs and providing vocational guidance for senior (Year12) students in the preparation for post-school transition. In Situ Biology Join Us Contact The Chen Lab. 46-1303 Cambridge, MA 02139 . Sheng received a B.A. A physician and a scientist, Morgan Shengis author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. The broad conservation of plant microbiota suggests that plants . This candidate will collaborate with biologists and geneticists to perform various . Standing could determine the Supreme Court ruling. Hansen DV, Hanson JE, Sheng M. J Cell Biol. $160,000.00. Dr. Sheng lab haspublisheda number of important studies focused on axonal transport of mitochondria and endolysosomes in healthy and diseased neurons. - Investigating stem cells, regeneration and ageing using Planarian flatworms. He will also return to MIT, after a decade in industry, as a professor of neuroscience in the Department of Brain and Cognitive Sciences, where he will be an affiliate of both the McGovern Institute for Brain Research and the Picower Institute for Learning and Memory. By the end of 2022, Broads COVID-19 testing lab had processed more than 37 million tests. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery. Morgans groundbreaking research has accelerated the understanding of brain synapses in health and disease, said Eric Lander. . The scope will include integration with other internal and external genomics datasets. Developing a resistant cultivar and inducing plant defenses by elicitor application are currently two of the best options to control this disease. lab studies the neural mechanisms of attention, learning, and memory . This candidate will collaborate with biologists and geneticists to perform various . 1 Broad Institute of MIT and . a professor of neuroscience in MITs Department of Brain and Cognitive Sciences, and an affiliate of both The Picower Institute for Learning and Memory and the McGovern Institute for Brain Research. Should have a demonstrated proficiency in R and/or Python, or related languages, Experience with and solid understanding of statistical analysis is required, Familiarity with next-generation sequence data analysis tools and packages, particularly those for bulk and single cell/nucleus RNA-seq, Understanding of molecular biology and next generation sequencing is highly preferred, Familiarity with working on a computing cluster/server (important skills: Unix/Linux, shell scripting). Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries. Click the link in the email we sent to to verify your email address and activate your job alert. By taking the advantage of next-generation sequencing technique, he uses bioinformatics approaches to investigate features of B cell repertoires, and to study mechanisms modulating the maturation process of broadly HIV-1 neutralizing antibody lineages in humans and animal models, with the aim of finding an optimal HIV . Morgan Sheng, Ph.D. Vice President of Neuroscience, Genentech, Inc., San Francisco, CA. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. He is also a professor of neuroscience in MIT's Department of Brain and Cognitive Sciences, and an . He completed his postdoctoral research with William Catterall at the University of Washington in 1996. Based on the above information, the Hydrus-2D model was established, then the study area was Jo ur na l P re -p ro of Journal Pre-proof 12 discretized and . +1 415 734-2717. Published by at July 3, 2022. Check out this video for a look into our community! The Broad Institute of MIT and Harvard is looking for an exceptional candidate to join the Sheng lab or the Therapeutics group (led by Professor Morgan Sheng) in the Stanley Center for Psychiatric Research . Massachusetts Institute of Technology 43 Vassar Street, Bldg. Eye and Ear Institute 915 Olentangy River Road Suite 4000 Columbus, OH 43212. . Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research. Broad Institute of MIT and Harvard; Simons Center for the Social Brain; Massachusetts Institute of Technology He is also a professor of neuroscience in MITs Department of Brain and Cognitive Sciences, and an affiliate of both The Picower Institute for Learning and Memory and the McGovern Institute for Brain Research. Broad-spectrum disease resistance conferred by expression of the Pseudomonas syringae hrmA gene in plants (2001) Qingshun Li, Songhai Shen, Arthur Hunt and Sheng Yang He. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa. About the Lab. Some of their efforts include multifunctional drug/agent nanocarriers for the . Postdoctoral Associate - Sheng Lab in The Broad Institute, Inc. Cambridge, MA. f. Those with underlying diseases should be treated accordingly. Shawn.Sheng@nrel.gov 303-384-7106 . Meet our members, staff scientists, fellows and other Broadies. Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. Lab Website molbiolabs.princeton.edu/cristea ; 3 NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen . Merkin Building Abudayyeh-Gootenberg lab, McGovern Institute, and Zhang lab, McGovern Institute/Broad Institute Gloria Choi Image credit: Justin Knight/McGovern Institute. Learn about our mission, leadership, history, and partner institutions. He joined Cornell University in 2003 where he is currently the William L. Lewis Professor of Engineering in the Robert F. Smith School of Chemical and Biomolecular . Popular Locations. Broad Institute of MIT and Harvard As Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Sheng will help to . Broad Institute 4.0. Dejanovic B, Huntley MA, De Mazire A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, Carano RAD, Chih B, Klumperman J, Bakalarski C, Hanson JE, Sheng M. Neuron. The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease. Sheng does research in Physical Chemistry, Solid-state Chemistry and Solid . Cambridge, MA 02142. A catalog of scientific papers published by our members and staff scientists. The Broad Institute of MIT and Harvard is looking for an exceptional candidate to join the Sheng lab or the Therapeutics group (led by Professor Morgan Sheng) in the Stanley Center for Psychiatric Research. Additionally, developing new . This person will apply existing computational methods and interpret results within a biological context. Learn about breakthroughs from Broad scientists. Researchers in the Sheng . Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research. Research Scientist I - Therapeutics Group - Sheng Lab. Using genetic mouse models, his group is addressing several fundamental questions: (1) how mitochondrial transport is regulated to sense changes in synaptic activity, mitochondrial integrity, axon injury and pathological stress; (2) how neurons coordinate late endocytic transport and autophagy-lysosomal function to maintain cellular homeostasis and distal degradation capacity; (3) how impaired transport contributes to synaptic dysfunction and axonal pathology in neurodegenerative diseases. Featured publications are below. Explore the connection between art and science and how we bring together artists and Broad scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations. (+1) 617-452-2588. Steven Hyman, M.D. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). 2 Zhejiang Sheng Ting Biotechnology Company, Hangzhou, Zhejiang, P. R. China. Fralin Biomedical Research Institute faculty conduct research in wet and dry labs in our 280,000-square-foot facilities . Oana Ursu Status: Postdoc, Aviv Regev lab, Broad Institute Lab Affiliation: PhD, Genetics Dept., Co-advised by Mike Snyder Sept 2013 - Mar 2018 (HHMI International Fellow) Research focus: 3D genome organization, enhancer-gene linking, regulatory . Lawrence Berkeley National Laboratory (LBNL), commonly referred to as the Berkeley Lab, is a United States national laboratory owned by, and conducting scientific research on behalf of, the United States Department of Energy.Located in the hills of Berkeley, California, the lab overlooks the campus of the University of California, Berkeley, and is managed by the University of California system. Blainey Lab Golub Lab Hung Lab Lander Lab Liu Lab Regev Lab Schreiber Lab Sellers Lab Xavier Lab Zhang Lab Institute Member labs Eric Alm, MIT Paola Arlotta, Harvard Picower Professor of Biology and Neuroscience; Director, RIKEN-MIT Laboratory for Neural Circuit Genetics. In collaboration with labs at ADARC, we sequence viral antigen-specific B cell receptors (BCRs) to identify immune signatures of infections including . He/she would address fundamental scientific questions, formulate hypotheses, design and execute experiments, interpret data, and write and publish original papers, often in teamwork with other lab members and external collaborators. Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research. Salary Company Resume Critique How To Become Job Openings. Raozhou Lin is a molecular neuroscientist with a keen interest in understanding the causes for neuropsychiatric diseases. The research of her group focuses on translating emerging genetics into biology and to enable next-generation . As Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Sheng will help to shape the centers scientific vision and direction, and oversee the centers efforts to develop therapeutics for schizophrenia and other serious mental illnesses. A past recipient of the Fondation Ipsen Prize in Neuronal Plasticity and the Young Investigator Award of the Society for Neuroscience, Sheng received a B.A. All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Sheng-Yong NIU | Cited by 405 | of Broad Institute of MIT and Harvard, MA | Read 19 publications | Contact Sheng-Yong NIU He is also. The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Neuron 29 (2), 353-366, 2001. In Situ Biology Join Us Contact The Chen Lab. Visit our free public educational space that showcases how researchers at the Broad and their colleagues around the world seek to understand and treat human disease. USA. His research at Genentech focused on human genetics and pathogenic mechanisms of neurodegenerative disease, particularly Alzheimers and Parkinsons diseases. The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The . Frequently searched careers. Ringel, Alison E. . Key scientific datasets and computational tools developed by our scientists and their collaborators. He received his PhD in Pharmacodymamics (with a focus onNeuroscience) from University of Lingling Yang is a research scientist I at the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, working under the direction of Jen Q. Pan. Broad Institute is committed to making the extensive data, methods, and technologies it generates rapidly and readily accessible to the scientific community to drive biomedical progress around the world . Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research. In the past few years, Pan has been working on genes whose dysfunction has been implicated for psychiatric illnesses using molecular, cellular, and electrophysiological approaches, both in vitro and in animals. He is affiliated with the Department of Electrical and Computer Engineering, Carle Illinois College of Medicine, Beckman Institute, and the Department of Bioengineering. Sheng's laboratory focuses on the mechanisms regulating axonal transport of mitochondria, endocytic organelles, and synaptic cargo and their impact on axonal homeostasis, synaptic function and neurodegeneration. Dr. Sheng received the 2021 Dr. Francisco S. Sy Award for Excellence in Mentorship at HHS. Howard Hughes Medical Institute, Duke University, Durham, NC, USA . Lab or Bio Link: Lihu Kolton Email: Postdoc 1983-1986: Patent Attorney, Ehrlich & Fenster: Website: Flora Katz . Since we are not allowed to take photos so only the photo from the outside is attached. Nonhematopoietic cells, including epithelial cells and stromal cells, are also important for enhancing or dampening inflammatory immune responses, especially at "barrier sites" such as the gastrointestinal (GI) tract and skin. We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries. Occupational field Manager: Technical Lead only 0.1% within United States work as Technical Lead. gu_hongcang@hotmail.com. 2018 Feb 5;217(2):459-472. doi: 10.1083/jcb.201709069. Dr. Shengreceived the2021 Dr. Francisco S. Sy Award for Excellence in Mentorship at HHS. We join with institutions and scientists the world over to address foundational challenges in science and health. He is also a professor of neuroscience in MITs Department of Brain and Cognitive Sciences, and an affiliate of both the McGovern Institute for Brain Research and the Picower Institute for Learning and Memory. Then she was a postdoctoral research scientist in the laboratory of Richard Axel at Columbia University. The mechanisms of chemical reactions, including the transformation pathways of the electronic and geometric structures of molecules, are crucial for comprehending the essence and developing new chemistry. View all Broad Institute jobs in Cambridge, MA - Cambridge jobs; Salary Search: Laboratory Operations Coordinator - Stanley Center salaries in Cambridge, MA; See popular questions & answers about Broad Institute; new. We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries. 2012 - 2017 Ershela Durresi, Ph.D. Medical Student, Harvard Medical School . Structural Insights of Non-canonical U-U Pair and Hoogsteen Interaction Probed with Se Atom. (1st class honors) from Oxford University and obtained his medical degree and training at London University. Prof. Gong's research group focuses on the design, synthesis/fabrication, and characterization of novel materials and devices. He has served on the editorial boards of Neuron, Journal of Neuroscience, and Current Opinions in Neurobiology. A catalog of scientific papers published by our members and staff scientists. Cambridge, MA 02142. EEO is The Law - click here for more information, Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled. 32. Kingston, Ontario, Canada. Eightformer trainees were appointed with faculty positions in an academic setting. All Rights Reserved. Merkin Building 415 Main St. The Farese/Walther lab studies lipid and energy metabolism in cells. University of Minnesota 4.2. his work to improve single-cell research protocols and technologies and how he transitioned from dentistry to life in a lab.Read more . The impact of Shengs research has been recognized by several prizes including the Fondation IPSEN Prize for Neuronal Plasticity and the Society for Neurosciences Young Investigator Award. Moreover, co-evolution between plants and microbes is greatly impacted by ongoing climate change. Laboratory Technician 1,190 job openings. However, research on the predictive potential and clinical importance of mitophagy-related genes (MRGs) in hepatocellular carcinoma (HCC) is currently lacking. We are a team of scientists studying the genetic basis and molecular mechanisms underlying schizophrenia and other brain disorders. 4.2 Laboratory diagnosis . The address is No. He has served as a mentor for 8 graduate students (NIH joint PhD Programs), 6 HHMI-NIH research scholars, and 20 postdoctoral fellows. Learn about Broad Institute's mentored research offerings for high school students, college students, and recent college graduates. The MIT Department of Biology ("Course VII") is a center for research and teaching in the life sciences. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. You can contact the company at 02 2245 3355.You can find more information about at www.sl-lab.com.tw. 69, Lide St. Zhonghe Dist., New Taipei City, TW. Steven E. Hyman, M.D., is a Harvard University Distinguished Service Professor of Stem Cell and Regenerative Biology and a Core Institute Member of the Broad Institute of Harvard and MIT, where he directs the Stanley Center for Psychiatric Research. Broad Institute of MIT and Harvard - Cited by 75,072 - neuroscience . Copyright 2008-2023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc, Computational Associate II, Stanley Center for Psychiatric Research, Title: Computational Associate II, Stanley Center for Psychiatric Research. This study aimed to uncover and analyze the mitophagy-related diagnostic biomarkers in HCC using . He has served on the editorial boards of Neuron, Journal of Neuroscience, and Current Opinions in Neurobiology. We are at a critical point where genetic and biological insights are emerging that can transform the way we study, diagnose, and treat mental illness. His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. Two new quarternary compounds, Ba23Ga10Ge10Sb25 and Ba23In10Ge10Sb24.79, have been synthesized by using the high temperature solid-state reactions. Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt, Borislav Dejanovic, Yiming Zhou, Christopher J. Bohlen, Seung-Hye Lee, Jingyi Ren, Albert Liu, Zefang Tang, Hao Sheng, Jia Liu, Morgan Sheng & Xiao Wang, Nat Neurosci (2023). From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. We are a team of scientists studying the genetic basis and molecular mechanisms underlying schizophrenia and other brain disorders. Get alerts to jobs like this, to your inbox. He completed his postdoctoral research with William Catterall at the University of Washington in 1996. The Sheng lab is a highly collegial and collaborative environment consisting of postdocs and graduate students who have the freedom to pursue a broad range of projects in the areas. Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. Neuron 2016 Jul 20;91(2):328-40. The Stanley Center engages in large-scale, globally conducted studies of . JR Lee, AW Dunah, M Sheng, E Kim. The Chen Lab. Dr. Sheng Ding is currently William K. Bowes, Jr. Cambridge, MA 02139-4307 |(617) 253-5748, For Emergencies|Accessibility|Adapting to COVID, A physician and a scientist, Morgan Sheng. Posted: December 20, 2022. In this paper, the effects of ultrasound frequency (17-25 kHz), power . Millions of years of co-evolution between plants and microbes have resulted in an intricate web of attack, counter-attack, decoy, and hijacking mechanisms in biology. In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. We are seeking a motivated Computational Associate II (CA) to join the Sheng Lab at the Broad Institute of MIT and Harvard. Chemical biology and therapeutics science, Genome regulation, cellular circuitry, and epigenomics, Merkin Institute for Transformative Technologies in Healthcare, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Several pre-existing RSV lineages powered the 2022 surge, Blood stem cells are susceptible to ferroptosis, a type of cell death, Rare genetic variants can reveal much about disease biology, Researchers map brain cell changes in Alzheimers disease. 617-714-7021. biology .mit .edu. His Ph.D. thesis was completed at Harvard Medical School in the lab of Michael Greenberg. Find our contact information, directions to our buildings, and directory. Broad brings people together to advance the understanding and treatment of disease. Following postdoctoral research in the lab of Lily Jan at the University of . Camelia is a computational scientist in the Neale lab at the Broad Institute of MIT . Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research.

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